Science Behind the Therapy
Wound Healing Begins at the Cellular Level
Understanding the Science of V.A.C. Therapy
With more than 715 peer-reviewed articles, the clinical and economic benefits of V.A.C.® (Vacuum Assisted Closure®) Therapy are widely known: faster20 and more effective5 than gauze11, 14, leading to improved patient quality of life1 and cost - effectiveness3. However, it is equally important to understand how V.A.C. Therapy works deep inside the wound to achieve the superior clinical outcomes. The following sections describe how V.A.C. Therapy promotes wound healing and how its unique mechanisms of action differentiate it from other Negative Pressure Wound Therapy devices.
- What Makes Up the V.A.C. Therapy System
- How V.A.C. Therapy Works on the Cellular Level
- How V.A.C. Therapy Removes Barriers to Healing
What Makes Up the V.A.C. Therapy System
Three Critical Components, One Unique Integrated System
The V.A.C. Therapy System is comprised of three essential components that actively work together to help wound healing through promotion of granulation tissue formation2, 12, 13.
- V.A.C. Therapy Unit Provides intermittent and continuous therapy with integrated patient safety features, delivering controlled negative (sub-atmospheric) pressure to the wound site
- SensaT.R.A.C. Technology Regulates the equal distribution of pressure across the wound area
- V.A.C. GranuFoam Dressings Ensures that fluid is continuously drawn away from the wound site , and is critical in the transmission of pressure, allowing for tissue micro deformation and cellular strain.
How V.A.C. Therapy Works at the Cellular Level
The Science Behind V.A.C. Therapy: Macrostrain and Microstrain
Under negative pressure, V.A.C. Therapy with proprietary V.A.C. GranuFoam™ Dressings applies both mechanical and biological forces to the wound to create an environment that promotes wound healing. These forces are known as macrostrain and microstrain.
Macrostrain is the visible alteration that occurs when negative pressure contracts the open pore V.A.C. foam dressing.
Macrostrain:
- Draws the wound edges together
- Provides direct and complete wound bed contact
- Evenly distributes negative pressure
- Removes wound exudate and materials which may cause infection
Microstrain is micro-deformation at the cellular level, which leads to cell stretch.
Microstrain:
- Reduces oedema
- Promotes perfusion
- Increases cellular proliferation and migration
- Promotes granulation tissue formation
Using V.A.C. Therapy with V.A.C. GranuFoam Dressings results in both macrostrain11, 16, 18 and microstrain11, 16, 18 for advanced wound healing.
Watch a video of how V.A.C. Therapy works at the cellular level through macrostrain and microstrain.
V.A.C. Therapy Mechanisms of Action – Transcription (RTF, 28.7 KB)
How V.A.C. Therapy Removes Barriers to Wound Healing
V.A.C. Therapy Mechanisms of Action
V.A.C. Therapy creates an environment that promotes wound healing through the following mechanisms:
| Wound Healing Barrier | V.A.C. Therapy Mechanism |
|---|---|
| Excessive bacterial burden | Removes infectious materials |
| Inadequate protection against infection | Provides a closed, protected wound healing environment |
| Excess exudate | Removes exudate |
| Excess oedema (interstitial fluid) | Reduces oedema (interstitial fluid) |
| Absence of moisture | Provides a moist wound healing environment |
| Lack of adequate blood flow | Promotes perfusion and angiogenesis |
| Lack of cellular activity | Promotes cellular migration and proliferation during granulation tissue formation |
SensaT.R.A.C. Technology
V.A.C. Therapy uses SensaT.R.A.C™ (Therapeutic Regulated Accurate Care) to:
- Monitor and maintain target pressure at the wound site for consistent therapy delivery
- Reduce tubing blockages and false alarms through enhanced fluid dynamics
- Enable use of Smart Alarms™ for increased patient safety
- Provide easier and more efficient V.A.C. dressing application
- Enhance patient comfort